SC Conference - Activity Details

High Performance Computing in the "Personalization" of Cancer Therapy: Genomics, Proteomics, and Bioinformatics

John N. Weinstein  (M. D. Anderson Cancer Center)
Masterworks Session
HPC in Biomedical Informatics II
Wednesday,  03:30PM - 04:15PM
Room 18A/18B/18C/18D
A major goal of current cancer research is to tailor treatment to the molecular profile of an individual patient's tumor. In the last dozen years, microarrays and other 'omic' technologies have made it possible to study tens of thousand of genes simultaneously. Consequently, for the first time in the history of biology, it's much easier, faster, and cheaper to generate information than it to analyze or interpret it. But that's only the beginning. High-throughput, deep sequencing, which is destined to replace many of the hybridization-based technologies such microarrays, is generating terabyte and petabyte digital databases that will transform our understanding of biological systems -- but will also further tax our hardware, software, and human resources. Tsunamis and fire hoses have been invoked to represent the situation visually. I'll describe our multifaceted molecular profiling of cancer cells and a set of tools and databases, the 'Miner Suite', that we've been developing for integrative ('integromic') analyses of the data. http://discover.nci.nih.gov.
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